Which one of the following statements concerning glycolysis is correct?
选项：

A:The conversion of glucose to lactate requires the presence of oxygen.
B:Hexokinase is improtant in hepatic glucose metabolism only in the absorptive period following consumption of a carbohydrate-containing meal.
C:Fructose 2,6-bisphosphate is a potent inhibitor of phosphofructokinase.
D:The rate-limiting reactions are also the irreversible reaction.
E:The conversion of glucose to lactate yields two ATP and two NADH