Which of the following statements about β-R blockers in the treatment of chronic heart failure is wrong?
选项：

A:β-R blockers are now considered first-line therapy for patients with class II to class III heart failure, especially for dilated cardiomyopathy.;
B:All β-R blockers have been proved useful to treat CH
F:;
C:Their anti-arrhythmia and anti-myocardial ischemia effects also benefit CHF patients.;
D:The adverse effects of β-blockers in patients with heart failure such as worsening of symptoms, may exist at beginning, but most patients (90%) can tolerate.;
E:β-R blockers should be combined with ACEI, diuretics or digoxin to palliate symptoms.