A 44-year-old woman has had tightening of the skin of her fingers for the past 2 years, making them difficult to bend。 She has had increasing difficulty swallowing for the past 8 months。 During the past winter, her fingers became cyanotic and painful on exposure to cold。 On physical examination, the skin on her face, neck, hands, and forearms appears firm and shiny。 Her blood pressure is 200/130 mm Hg。 A chest radio graph shows prominent interstitial markings, and lung func tion tests indicate moderately severe restrictive pulmonary disease。 The result of her DNA topoisomerase I antibody test is positive。 Which of the following conditions is she most likely to have?
选项：

A:Ankylosing spondylitis
B:Diffuse scleroderma
C:Discoid lupus erythematosus
D:Limited scleroderma
E:Rheumatoid arthritis
F:Systemic lupus erythematosus