Which of the following statements is wrong about ischemia-reperfusion?
选项：

A:Ischemia-reperfusion must cause tissue injury;
B:Ischemia-reperfusion injury can cause apoptosis;
C:Ischemic preconditioning can reduce or prevent ischemia-reperfusion injury;
D:Free radicals and calcium overload are the main mechanisms of ischemia-reperfusion injury;
E:Ischemia-reperfusion injury has universality of species and organs