Low-molecular-weight heparin (LMWH), is recommended as a prophylaxis against venothrombus disease in patients undergoing lower limb replacement arthroplasty.Which one of the following statements is true about the coagulation cascade?
选项：

A: LMWH directly inhibits factor Xa
B: Antithrombin III and protein C deficiencies predispose to bleeding
C: Factor VIII is synthesised in the vascular endothelium
D: Fibrinogen cleaves prothrombin to yield thrombin
E: The intrinsic pathway includes factor VII and tissue factor