A 22-year-old woman has had increasing malaise and swelling of her feet for the past week. On physical exami- nation, she has 2+ pitting edema to the knees and puffiness around the eyes. Laboratory studies show serum creatinine of 4.6 mg/dL and urea nitrogen of 42 mg/dL. A renal biopsy specimen shows positive immunofluorescent staining for im- munoglobulin and complement C3 within the glomeruli. The electron microscopic appearance of a glomerulus is shown in the figure. Which of the following immunologic mechanisms has most likely produced the renal damage seen in this patient?
选项:
A: Antibody-dependent cell-mediated cytotoxicity
B: Granulomatous inflammation
C: Immune complex–mediated hypersensitivity
D: Localized anaphylaxis
E: T cell–mediated cytotoxicity
发布时间:2024-06-19 18:43:25